Propyl pyrazole triol
Cat. No.：YN480082
CAS No. ：263717-53-9
规格
价格(RMB)
库存
| 产品名称: | Propyl pyrazole triol |
| CAS No.: | 263717-53-9 |
| Chemical Name: | 4,4',4''-(4-propyl-1H-pyrazole-1,3,5-triyl)tris-phenol |
| Synonyms: | PPT |
| 分子量: | 386.44 |
| 分子式: | C₂₄H₂₂N₂O₃ |
| SMILES: | CCCC1=C(C2=CC=C(O)C=C2)N(C3=CC=C(O)C=C3)N=C1C4=CC=C(O)C=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Propyl pyrazole triol (PPT) 是一种选择性的雌激素受体 α(ERα)激动剂。Propyl pyrazole triol (PPT) 对 ERα 的相对结合亲和力 (ERα: 49%) 是雌激素受体 β (ERβ: 0.12%) 的 410 倍。 |
| IC50和靶点: | |
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Stauffer, S.R., Coletta, C.J., Tedesco, R., et al.Pyrazole ligands: Structure-affinity/activity relationships and estrogen receptor-α-selective agonistsJ. Med. Chem.43,4934-4947(2000)
Meyers, M.J., Sun, J., Carlson, K.E., et al.Estrogen receptors-β potency-selective ligands: Structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogusJ. Med. Chem.44,4230-4251(2001)
Booth, E.A., Obeid, N.R., and Lucchesi, B.R.Activation of estrogen receptor-α protects the in vivo rabbit heart from ischemia-reperfusion injuryAm. J. Physiol.289,H2039-H2047(2005)
