G15
Cat. No.：YN480245
CAS No. ：1161002-05-6
规格
价格(RMB)
库存
| 产品名称: | G15 |
| CAS No.: | 1161002-05-6 |
| Chemical Name: | (3aS,4R,9bR)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline |
| Synonyms: | (3aS*,4R*,9bR*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta[c]quinoline;(3aS,4R,9bR)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline;(3aR,4R,9bS)-4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclope |
| 分子量: | 370.24 |
| 分子式: | C₁₉H₁₆BrNO₂ |
| SMILES: | BrC1=C([C@@H]2NC3=C(C=CC=C3)[C@@]4([H])[C@]2([H])CC=C4)C=C5OCOC5=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | G15 是一种高亲和力和选择性 G 蛋白偶联雌激素受体(GPER/GPR30)拮抗剂，Ki值为 20 nM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Filardo, E.J., and Thomas, P.Minireview: G protein-coupled estrogen receptor-1, GPER-1: Its mechanism of action and role in female reproductive cancer, renal and vascular physiologyEndocrinology153(7),2953-2962(2012)
Chevalier, N., Vega, A., Bouskine, A., et al.GPR30, the non-classical membrane G protein related estrogen receptor, is overexpressed in human seminoma and promotes seminoma cell proliferationPLoS One7(4),34672(2012)
Dennis, M.K., Burai, R., Ramesh, C., et al.In vivo effects of a GPR30 antagonistNat. Chem. Biol.5(6),421-427(2009)
Dennis, M.K., Field, A.S., Burai, R., et al.Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivityJ. Steroid Biochem. Mol. Biol.127(3-5),358-366(2011)
