XCT790
Cat. No.：YN480267
CAS No. ：725247-18-7
规格
价格(RMB)
库存
| 产品名称: | XCT790 |
| CAS No.: | 725247-18-7 |
| Chemical Name: | 3-[4-[[2,4-bis(trifluoromethyl)phenyl]methoxy]-3-methoxyphenyl]-2-cyano-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]-2-propenamide |
| Synonyms: | Compound 12 |
| 分子量: | 596.42 |
| 分子式: | C₂₃H₁₃F₉N₄O₃S |
| SMILES: | O=C(NC1=NN=C(C(F)(F)F)S1)/C(C#N)=C/C2=CC=C(OCC3=C(C(F)(F)F)C=C(C(F)(F)F)C=C3)C(OC)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | XCT-790 是ERRα的有效选择性反向激动剂，IC50值为 0.37 μM。XCT-790 在化疗过程中诱导癌细胞死亡。XCT-790 对 ERRγ 和雌激素受体 ERα 和 ERβ 无活性。 |
| IC50和靶点: | [{name:"ERRα:0.37 μM (IC50)"}] |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Busch, B.B., Stevens, W.C., Jr., Martin, R., et al.Identification of a selective inverse agonist for the orphan nuclear receptor estrogen-related receptor αJ. Med. Chem.47(23),5593-5596(2004)
Willy, P.J., Murray, I.R., Qlan, J., et al.Regulation of PPARγ coactivator 1α (PGC-1α) signaling by an estrogen-related receptor α (ERRα) ligandProc. Natl. Acad. Sci. USA101(24),8912-8917(2004)
Lanvin, O., Bianco, S., Kersual, N., et al.Potentiation of ICI182,780 (Fulvestrant)-induced estrogen receptor-α degradation by the estrogen receptor-related receptor-α inverse agonist XCT790J. Biol. Chem.282(39),28328-28334(2007)
