AZD9496
Cat. No.：YN480944
CAS No. ：1639042-08-2
规格
价格(RMB)
库存
| 产品名称: | AZD9496 |
| CAS No.: | 1639042-08-2 |
| Chemical Name: | (2E)-3-[3,5-difluoro-4-[(1R,3R)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1H-pyrido[3,4-b]indol-1-yl]phenyl]-2-propenoic acid |
| Synonyms: | 3-[3,5-Difluoro-4-[(1r,3r)-2-(2-fluoro-2-methylpropyl)-2,3,4,9-tetrahydro-3-methyl-1h-pyrido[3,4-b]indol-1-yl]phenyl]-2-propenoic acid;AZD9496;(E)-3-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-y |
| 分子量: | 442.47 |
| 分子式: | C₂₅H₂₅F₃N₂O₂ |
| SMILES: | O=C(O)/C=C/C1=CC(F)=C([C@H]2N(CC(C)(F)C)[C@H](C)CC3=C2NC4=C3C=CC=C4)C(F)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AZD9496 是有效,选择性的雌激素受体 (ERα) 拮抗剂，IC50为 0.28 nM。AZD9496 是一种口服有效的选择性雌激素受体降解剂 (SERD) |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
De Savi, C., Bradbury, R.H., Rabow, A.A., et al.Optimization of a novel binding motif to (E)-3-(3,5-difluoro-4-((1R,3R)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)phenyl)acrylic acid (AZD9496), a potent and orally bioavailable selective estrogen receptor downregulator and antagonistJ. Med. Chem.58(20),8128-8140(2015)
