Fulvestrant
Cat. No.：YN481286
CAS No. ：129453-61-8
规格
价格(RMB)
库存
| 产品名称: | Fulvestrant |
| CAS No.: | 129453-61-8 |
| Chemical Name: | 7α-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]-estra-1,3,5(10)-triene-3,17β-diol |
| Synonyms: | 氟维司群; ICI 182780; ZD 9238; ZM 182780 |
| 分子量: | 606.77 |
| 分子式: | C₃₂H₄₇F₅O₃S |
| SMILES: | C[C@@]12[C@@H](O)CC[C@@]1([H])[C@]3([H])[C@H](CCCCCCCCCS(CCCC(F)(F)C(F)(F)F)=O)CC4=C(C=CC(O)=C4)[C@@]3([H])CC2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Fulvestrant (ICI 182780) 是一种纯抗雌激素，也是一种有效的雌激素受体 (ER) 拮抗剂，IC50为 9.4 nM。Fulvestrant 有效抑制ER阳性 MCF-7 细胞的生长，IC50为 0.29 nM。Fulvestrant 还可诱导细胞自噬 (autophagy) 和凋亡 (apoptosis)，并具有抗肿瘤功效。 |
| IC50和靶点: | |
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Wardell, S.E., Marks, J.R., and McDonnell, D.P.The turnover of estrogen receptor α by the selective estrogen receptor degrader (SERD) fulvestrant is a saturable process that is not required for antagonist efficacyBiochem. Pharmacol.82(2),122-130(2011)
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Zhao, L., O'Neill, K., and Brinton, R.D.Estrogenic agonist activity of ICI 182,780 (Faslodex) in hippocampal neurons: Implications for basic science understanding of estrogen signaling and development of estrogen modulators with a dual therapeutic profileJ. Pharmacol. Exp. Ther.319(3),1124-1132(2006)
