Acolbifene
Cat. No.：YN481524
CAS No. ：182167-02-8
规格
价格(RMB)
库存
| 产品名称: | Acolbifene |
| CAS No.: | 182167-02-8 |
| Chemical Name: | (2S)-3-(4-hydroxyphenyl)-4-methyl-2-[4-[2-(1-piperidinyl)ethoxy]phenyl]-2H-1-benzopyran-7-ol |
| Synonyms: | EM-652; SCH 57068 |
| 分子量: | 457.56 |
| 分子式: | C₂₉H₃₁NO₄ |
| SMILES: | OC1=CC=C2C(C)=C(C3=CC=C(O)C=C3)[C@H](C4=CC=C(OCCN5CCCCC5)C=C4)OC2=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Acolbifene (EM-652; SCH 57068) 是第四代选择性的estrogen receptor拮抗剂，LC50值为 22 nM。 |
| IC50和靶点: | [{name:"ERα:2 nM (IC50, E2-induced transcriptional activity)"},{name: "ERβ:0.4 nM (IC50, E2-induced transcriptional activity)"}] |
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| Solvent & Solubility: |
Labrie, F., Labrie, C., Bélanger, A., et al.EM-652 (SCH 57068), a third generation SERM acting as pure antiestrogen in the mammary gland and endometriumJ. Steroid Biochem. Mol. Biol.69(1-6),51-84(1999)
Martel, C., Provencher, L., Li, X., et al.Binding characteristics of novel nonsteroidal antiestrogens to the rat uterine estrogen receptorsJ. Steroid Biochem. Mol. Biol.64(3-4),199-205(1998)
Gutman, M., Couillard, S., Roy, J., et al.Comparison of the effects of EM-652 (SCH57068), tamoxifen, toremifene, droloxifene, idoxifene, GW-5638 and raloxifene on the growth of human ZR-75-1 breast tumors in nude miceInt. J. Cancer99(2),273-278(2002)
