4-Hydroxytamoxifen
Cat. No.：YN481569
CAS No. ：68047-06-3
规格
价格(RMB)
库存
| 产品名称: | 4-Hydroxytamoxifen |
| CAS No.: | 68047-06-3 |
| Chemical Name: | 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol |
| Synonyms: | 4-羟基他莫昔芬; (Z) |
| 分子量: | 387.51 |
| 分子式: | C₂₆H₂₉NO₂ |
| SMILES: | CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C)C=C2)\C3=CC=C(O)C=C3.[(Z)] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 4-Hydroxytamoxifen是一种选择性的雌激素受体调节剂 (SERM)。 |
| IC50和靶点: | [{name:"Estrogen receptor:3.3 nM (IC50)'}, 'CRISPR/Cas9'] |
| In Vitro: | |
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| Solvent & Solubility: |
Crewe, H.K., Notley, L.M., Wunsch, R.M., et al.Metabolism of tamoxifen by recombinant human cytochrome P450 enzymes: Formation of the 4-hydroxy, 4'-hydroxy and N-desmethyl metabolites and isomerization of trans-4-hydroxytamoxifenDrug Metab. Dispos.30(8),869-874(2002)
Desta, Z., Ward, B.A., Soukhova, N.V., et al.Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: Prominent roles for CYP3A and CYP2D6J. Pharmacol. Exp. Ther.310(3),1062-1075(2004)
Y.C., L., Desta, Z., Flockhart, D.A., et al.Endoxifen (4-hydroxy-N-desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifenCancer Chemother. Pharmacol.55(5),471-478(2005)
Urbinati, G., Audisio, D., Marsaud, V., et al.Therapeutic potential of new 4-hydroxy-tamoxifen-loaded pH-gradient liposomes in a multiple myeloma experimental modelPharm. Res.27(2),327-339(2010)
