Bazedoxifene
Cat. No.：YN481744
CAS No. ：198481-32-2
规格
价格(RMB)
库存
| 产品名称: | Bazedoxifene |
| CAS No.: | 198481-32-2 |
| Chemical Name: | WAY 140424; 1-[[4-[2-(Hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol; 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol |
| Synonyms: | 巴多昔芬; TSE-424 |
| 分子量: | 470.60 |
| 分子式: | C₃₀H₃₄N₂O₃ |
| SMILES: | CC1=C(C2=CC=C(O)C=C2)N(CC3=CC=C(OCCN4CCCCCC4)C=C3)C5=CC=C(O)C=C51 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bazedoxifene (TSE-424) 是一种有口服活性的，能透过血脑屏障的，非甾体、选择性的雌激素受体调节剂 (SERM)，对 ERα 和 ERβ 作用的IC50值分别为 26 nM 和 99 nM，可用于骨质疏松症的研究。Bazedoxifene 也是一种IL-6/GP130蛋白相互作用抑制剂，可用于胰腺癌的研究。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
van Hoorn, W., et al.: J. Med. Chem., 45, 584
