Bazedoxifene acetate
Cat. No.：YN481746
CAS No. ：198481-33-3
规格
价格(RMB)
库存
| 产品名称: | Bazedoxifene acetate |
| CAS No.: | 198481-33-3 |
| Chemical Name: | 1-[[4-[2-(hexahydro-1H-azepin-1-yl)ethoxy]phenyl]methyl]-2-(4-hydroxyphenyl)-3-methyl-1H-indol-5-ol, acetate |
| Synonyms: | TSE-424 acetate |
| 分子量: | 530.65 |
| 分子式: | C₃₂H₃₈N₂O₅ |
| SMILES: | CC1=C(C2=CC=C(O)C=C2)N(CC3=CC=C(OCCN4CCCCCC4)C=C3)C5=CC=C(O)C=C51.CC(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bazedoxifene acetate (TSE-424 acetate) 是一种有口服活性的，非甾体、选择性的雌激素受体调节剂 (SERM)，对 ERα 和 ERβ 作用的IC50值分别为 26 nM 和 99 nM，可用于骨质疏松症的研究。Bazedoxifene acetate 也是一种IL-6/GP130蛋白相互作用抑制剂，可用于胰腺癌的研究。 |
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Komm, B.S., Kharode, Y.P., Bodine, P.V.N., et al.Bazedoxifene acetate: A selective estrogen receptor modulator with improved selectivityEndocrinology146(9),3999-4008(2005)
Lewis-Wambi, J.S., Kim, H., Curpan, R., et al.The selective estrogen receptor modulator bazedoxifene inhibits hormone-independent breast cancer cell growth and down-regulates estrogen receptor α and cyclin D1Mol. Pharmacol.80(4),610-620(2011)
