ULS 欢迎您!
ULS 欢迎您!
> 产品中心 > 抑制剂 & 激动剂 > Others > Aromatase

Alpha-Naphthoflavone

Cat. No.:YN480847

  • CAS No. :604-59-1

    • 规格

      价格(RMB)

      库存

    • 产品资料
    • 生物活性
    • 参考文献
    • 产品名称: Alpha-Naphthoflavone
      CAS No.: 604-59-1
      Chemical Name: 2-phenyl-4H-naphtho[1,2-b]pyran-4-one
      Synonyms:α-萘黄酮
      分子量:272.30
      分子式:C₁₉H₁₂O₂
      SMILES:O=C1C=C(C2=CC=CC=C2)OC3=C1C=CC4=CC=CC=C43
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
      Select Batch:
      Purity: 98%
    • 产品描述: Alpha-Naphthoflavone 是一种合成的黄酮类化合物,为有效、竞争性的芳香酶aromatase抑制剂,IC50和Ki值分别为 0.5 和 0.2 μM。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Denison, M.S., and Nagy, S.R.Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicalsAnnu. Rev. Pharmacol. Toxicol.43,309-334(2003)

      Smith, K.J., Murray, I.A., Tanos, R., et al.Identification of a high-affinity ligand that exhibits complete aryl hydrocarbon receptor antagonismJ. Pharmacol. Exp. Ther.338(1),318-327(2011)

      Wilhelmsson, A., Whitelaw, M.L., Gustafsson, J.A., et al.Agonistic and antagonistic effects of α-naphthoflavone on dioxin receptor function. Role of the basic region helix-loop-helix dioxin receptor partner factor ArntJ. Biol. Chem.269(29),19028-19033(1994)

      Bruno, R.D., and Njar, V.C.O.Targeting cytochrome P450 enzymes: A new approach in anti-cancer drug developmentBioorg. Med. Chem.15(15),5047-5060(2007)

      Campbell, D.R., and Kurzer, M.S.Flavonoid inhibition of aromatase enzyme activity in human preadipocytesJ. Steroid Biochem. Mol. Biol.46(3),381-388(1993)

      Sineva, E.V., Rumfeldt, J.A.O., Halpert, J.R., et al.A large-scale allosteric transition in cytochrome P450 3A4 revealed by luminescence resonance energy transfer (LRET)PLoS One8(12),1-13(2013)

      Metzler, M., Blaich, G., and Tritscher, A.M.Role of metabolic activation in the carcinogenicity of estrogens: Studies in an animal liver tumor modelEnviron. Health Perspect.88,117-121(1990)

    • 摩尔计算器
    • 稀释计算器
    摩尔浓度计算器方程 :
    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    计算

    质量 浓度 体积 分子量
    稀释计算器 :
    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
    • C1
      V1
      C2
      V2
    • 您最近查看的产品:


    ULS 的所有产品和服务仅用于科学研究,我们不为任何其他用途提供产品和服务(也不为任何个人提供产品和服务)Copyright © 2020-2021 ULS. All Rights Reserved. 备案号:粤ICP备2021013238号-1
    0.325545s