IMD-0354
Cat. No.：YN410006
| 产品名称: | IMD-0354 |
| CAS No.: | 978-62-1 |
| Chemical Name: | N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxy-benzamide |
| Synonyms: | IKK2 Inhibitor V |
| 分子量: | 383.67 |
| 分子式: | C₁₅H₈ClF₆NO₂ |
| SMILES: | O=C(NC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)C2=CC(Cl)=CC=C2O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | IMD-0354 (IKK2 Inhibitor V) 是一种选择性IKKβ抑制剂，抑制 NF-κB 活性。IMD0354 抑制 TNF-α 诱导的 NF-κB 转录活性，IC50为 1.2 μM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Onai, Y., Suzuki, J.i., Kakuta, T., et al.Inhibition of IκB phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injuryCardiovasc. Res.63(1),51-59(2004)
Tanaka, A., Muto, S., Konno, M., et al.A new IκB kinase β inhibitor prevents human breast cancer progression through negative regulation of cell cycle transitionCancer Res.66(1),419-426(2006)
Kanduri, M., Tobin, G., Åleskog, A., et al.The novel NF-κB inhibitor IMD-0354 induces apoptosis in chronic lymphocytic leukemiaBlood Cancer J.1(3),1-6(2011)
