BMS-345541 hydrochloride
Cat. No.：YN410010
CAS No. ：547757-23-3
| 产品名称: | BMS-345541 hydrochloride |
| CAS No.: | 547757-23-3 |
| Chemical Name: | N1-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine, monohydrochloride |
| Synonyms: | N-(1,8-二甲基咪唑并[1,2-A]喹喔啉-4-基)-1,2-乙二胺盐酸盐 |
| 分子量: | 291.78 |
| 分子式: | C₁₄H₁₈ClN₅ |
| SMILES: | CC1=CN=C2C(NCCN)=NC3=CC=C(C=C3N21)C.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BMS-345541 hydrochloride 是一种选择性的IKK催化亚基 IKK-1 和 IKK-2 抑制剂，抑制IKK-2和IKK-1，IC50值分别为 0.3 μM 和 4 μM。BMS-345541 与 IKK 的变构位点结合。 |
| IC50和靶点: | [{name:"IKK-2:0.3 μM (IC50)"},{name: "IKK-1:4 μM (IC50)"}] |
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Burke, J.R., Pattoli, M.A., Gregor, K.R., et al.BMS-345541 is a highly selective inhibitor of IκB kinase that binds at an allosteric site of the enzyme and blocks NF-κB-dependent transcription in miceJ. Biol. Chem.278(3),1450-1456(2003)
McIntyre, K.W., Shuster, D.J., Gillooly, K.M., et al.A highly selective inhibitor of IκB kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in miceArthritis Rheum.48(9),2652-2659(2003)
Yang, J., Amiri, K.I., Burke, J.R., et al.BMS-345541 targets inhibitor of κB kinase and induces apoptosis in melanoma: Involvement of nuclear factor κB and mitochondria pathwaysClin. Cancer Res.12(3 Pt 1),950-960(2006)
Karim, Z.A., Zhang, J., Bangerjee, M., et al.IκB kinase phosphorylation of SNAP-23 controls platelet secretionBlood121(22),4567-4574(2013)
Wen, L., Zhu, M., Madigan, M.C., et al.Immunomodulatory effects of bone marrow-derived mesenchymal stem cells on pro-inflammatory cytokine-stimulated human corneal epithelial cellsPLoS One9(7),1-12(2014)
