BAY-985
Cat. No.：YN410046
CAS No. ：2409479-29-2
| 产品名称: | BAY-985 |
| CAS No.: | 2409479-29-2 |
| Chemical Name: | 1-[4-[(1R)-1-[2-[[6-[6-(dimethylamino)-4-pyrimidinyl]-1H-benzimidazol-2-yl]amino]-4-pyridinyl]ethyl]-1-piperazinyl]-3,3,3-trifluoro-1-propanone |
| Synonyms: | BAY985;BAY 985 |
| 分子量: | 553.58 |
| 分子式: | C₂₇H₃₀F₃N₉O |
| SMILES: | O=C(N1CCN([C@@H](C2=CC(NC3=NC4=CC=C(C5=NC=NC(N(C)C)=C5)C=C4N3)=NC=C2)C)CC1)CC(F)(F)F |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BAY-985 是一种高效的，有口服活性的、ATP 竞争性的，选择性TBK1和IKKε双重抑制剂，对 TBK1 (在低/高 ATP 实验中) 和 IKKε 的IC50分别为 2/30 和 2 nM。BAY-985 具有抗肿瘤功效。 |
| IC50和靶点: | [{name:"TBK1:2 nM (IC50, low ATP)"},{name: "TBK1:30 nM (IC50, high ATP)"},{name: "IKKε:2 nM (IC50)"}] |
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| Solvent & Solubility: |
Lefranc, J., Schulze, V.K., Hillig, R.C., et al.Discovery of BAY-985, a highly selective TBK1/IKKε inhibitorJ. Med. Chem.63(2),601-612(2020)
