BAY 11-7082
Cat. No.：YN410051
CAS No. ：19542-67-7
| 产品名称: | BAY 11-7082 |
| CAS No.: | 19542-67-7 |
| Chemical Name: | 3-[(4-methylphenyl)sulfonyl]-(2E)-propenenitrile |
| Synonyms: | BAY 11-7821 |
| 分子量: | 207.25 |
| 分子式: | C₁₀H₉NO₂S |
| SMILES: | N#C/C=C/S(=O)(C1=CC=C(C)C=C1)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | BAY 11-7082 (BAY 11-7821) 是一种IκBα磷酸化和NF-κB抑制剂，选择性且不可逆地抑制 TNF-α 诱导的 IκB-α 磷酸化，并减少 NF-κB 和粘附分子的表达。BAY 11-7082 抑制泛素特异性蛋白酶USP7和USP21(IC50分别为 0.19, 0.96 μM)。BAY 11-7082 抑制脂质体中的gasdermin D (GSDMD)孔形成以及炎性体介导的细胞凋亡和人和小鼠细胞中IL-1β的分泌。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Pahl, H.L.Activators and target genes of Rel/NF-κB transcription factorsOncogene18,6853-6866(1999)
Gilmore, T.D.The Rel/NF-κB signal transduction pathway: IntroductionOncogene18,6842-6844(1999)
Karin, M.The beginning of the end: IκB kinase (IKK) and NF-κB activationJ. Biol. Chem.274(39),27339-27342(1999)
Pierce, J.W., Schoenleber, R., Jesmok, G., et al.Novel inhibitors of cytokine-induced IκBα phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivoJ. Biol. Chem.272(34),21096-21103(1997)
