GSK319347A
Cat. No.：YN410065
| 产品名称: | GSK319347A |
| CAS No.: | 862812-98-4 |
| Chemical Name: | 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarbonitrile |
| Synonyms: | GSK-319347A; GSK-319347A; GSK-319347A; |
| 分子量: | 469.53 |
| 分子式: | C₂₂H₁₉N₃O₅S₂ |
| SMILES: | COC1=CC2=C(C=C1OC)N(C3=CC(OCC4=CC=CC=C4S(=O)(C)=O)=C(C#N)S3)C=N2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK319347A 是TBK1和IKKε的双重抑制剂，IC50分别为 93 nM 和 469 nM。 GSK319347A 还抑制IKK2，IC50为 790 nM。 |
| IC50和靶点: | [{name:"TBK1:93 nM (IC50)"},{name: "IKK-ε:469 nM (IC50)"},{name: "IKK2:790 nM (IC50)"}] |
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| Solvent & Solubility: |
Bamborough, P., Christopher, J.A., Cutler, G.J., et al.5-(1H-benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinaseBioorg. Med. Chem. Lett.16(24),6236-6240(2006)
Xie, H.-Z., Liu, L.-Y., Ren, J.-X., et al.Pharmacophore modeling and hybrid virtual screening for the discovery of novel IκB kinase 2 (IKK2) inhibitorsJ. Biomol. Struct. Dyn.29(1),165-179(2011)
Johannes, J.W., Chuaqui, C., Cowen, S., et al.Discovery of 6-aryl-azabenzimidazoles that inhibit the TBK1/IKK-ε kinasesBioorg. Med. Chem. Lett.24(4),1138-1143(2014)
Wang, P., Yang, Y., Shao, Q., et al.Selective inhibition of ROCK kinase isoforms to promote neuroregeneration after brain surgeryMed. Chem. Res.25,40-50(2016)
