MLN120B
Cat. No.：YN410067
CAS No. ：783348-36-7
| 产品名称: | MLN120B |
| CAS No.: | 783348-36-7 |
| Chemical Name: | (9CI, ACI)-N-(6-chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methyl-3-pyridinecarboxamide |
| Synonyms: | ML120B |
| 分子量: | 366.80 |
| 分子式: | C₁₉H₁₅ClN₄O₂ |
| SMILES: | O=C(C1=CC=CN=C1C)NC2=C(OC)C(Cl)=CC3=C2NC4=C3C=CN=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MLN120B (ML120B) 是一种有效的、ATP 竞争性的和具有口服活性的IKKβ抑制剂，IC50为 60 nM。MLN120B 在体内外抑制多发性骨髓瘤细胞生长，也可用于类风湿关节炎的相关研究。 |
| IC50和靶点: | [{name:"IKKβ:60 nM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Wen, D., Nong, Y., Morgan, J.G., et al.A selective small molecule IκB kinase β inhibitor blocks nuclear factor κB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cellsJ. Pharmacol. Exp. Ther.317(3),989-1001(2006)
Hideshima, T., Neri, P., Tassone, P., et al.MLN120B, a novel IκB kinase β inhibitor, blocks multiple myeloma cell growth in vitro and in vivoClin Cancer Res.12(19),5887-5894(2006)
Schopf, L., Savinainen, A., Anderson, K., et al.Iκκβ inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritisArthirits Rheum.54(10),3163-3173(2006)
