PS-1145
Cat. No.：YN410075
CAS No. ：431898-65-6
| 产品名称: | PS-1145 |
| CAS No.: | 431898-65-6 |
| Chemical Name: | N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide |
| Synonyms: | IKK Inhibitor X |
| 分子量: | 322.75 |
| 分子式: | C₁₇H₁₁ClN₄O |
| SMILES: | O=C(C1=CC=CN=C1)NC2=CC(Cl)=CC3=C2NC4=C3C=CN=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PS-1145 是一种 IκB 激酶 (IKK) 抑制剂，IC50为 88 nM。 |
| IC50和靶点: | [{name:"IKK:88 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Hideshima, T., Chauhan, D., Richardson, P., et al.NF-κB as a therapeutic target in multiple myelomaJ. Biol. Chem.277(19),16639-16647(2002)
Castro, A.C., Dang, L.C., Soucy, F., et al.Novel IKK inhibitors: β-carbolinesBioorg. Med. Chem. Lett.13(14),2419-2422(2003)
Tsunekage, Y., Takeiri, M., Yoshioka, Y., et al.Nasturtium officinale extract suppresses osteoclastogenesis in RAW 264 cells by inhibiting IκB-kinase βNat. Prod. Commun.16(6),1-9(2021)
