Amlexanox
Cat. No.：YN410084
CAS No. ：68302-57-8
| 产品名称: | Amlexanox |
| CAS No.: | 68302-57-8 |
| Chemical Name: | 2-amino-7-(1-methylethyl)5-oxo-5H-[1]benzopyrano[2,3-b]pyridine-3-carboxylic acid |
| Synonyms: | 氨来呫诺; AA673; Amoxanox; CHX3673 |
| 分子量: | 298.29 |
| 分子式: | C₁₆H₁₄N₂O₄ |
| SMILES: | O=C(C1=C(N)N=C2C(C(C3=CC(C(C)C)=CC=C3O2)=O)=C1)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Amlexanox (AA673; Amoxanox; CHX3673) 是特异性的IKKε和TBK1抑制剂，IC50值为 1-2 μM。 |
| IC50和靶点: | [{name:"IKKε:1-2 μM (IC50)"},{name: "TBK1:1-2 μM (IC50)"}] |
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Bell, J.Amlexanox for the treatment of recurrent aphthous ulcersClin. Drug Investig.25(9),555-566(2005)
Iwama, T., Komatsu, N., Shikada, K.i., et al.Reversing effect of anti-asthmatic drugs on bronchoconstriction induced by antigen challenge and histamine in anesthetized guinea pigsJpn. J. Pharmacol.58,19-25(1992)
Shishibori, T., Oyama, Y., Matsushita, O., et al.Three distinct anti-allergic drugs, amlexanox, cromolyn and tranilast, bind to S100A12 and S100A13 of the S100 protein familyBiochem. J.338,583-589(1999)
Landriscina, M., Prudovsky, I., Carreira, C.M., et al.Amlexanox reversibly inhibits cell migration and proliferation and induces the Src-dependent disassembly of actin stress fibers in vitroJ. Biol. Chem.275(42),32753-32762(2000)
Reilly, S.M., Chiang, S.H., Decker, S.J., et al.An inhibitor of the protein kinases TBK1 and IKK-ε improves obesity-related metabolic dysfunctions in miceNat. Med.,(2013)
