AEM1
Cat. No.：YN410158
CAS No. ：1030123-90-0
| 产品名称: | AEM1 |
| CAS No.: | 1030123-90-0 |
| Chemical Name: | N-(1,3-benzodioxol-5-ylmethyl)-5-(4-fluorophenyl)-thieno[2,3-d]pyrimidin-4-amine |
| Synonyms: | |
| 分子量: | 379.4 |
| 分子式: | C20H14FN3O2S |
| SMILES: | FC(C=C1)=CC=C1C2=CSC3=C2C(NCC4=CC=C(OCO5)C5=C4)=NC=N3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AEM1 是一种Nrf2抑制剂。AEM1 降低 A549 细胞中 Nrf2 依赖基因的表达，并在体外和体内抑制 A549 细胞的生长。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
DeNicola, G.M., Karreth, F.A., Humpton, T.J., et al.Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesisNature475(7354),106-109(2011)
Bollong, M.J., Yun, H., Sherwood, L., et al.A small molecule inhibits deregulated NRF2 transcriptional activity in cancerACS Chem. Biol.10(10),2193-2198(2015)
