EUK-134
Cat. No.：YN410178
CAS No. ：81065-76-1
| 产品名称: | EUK-134 |
| CAS No.: | 81065-76-1 |
| Chemical Name: | chloro[[2,2'-[1,2-ethanediylbis[(nitrilo-κN)methylidyne]]bis[6-methoxyphenolato-κO]]]-manganese |
| Synonyms: | |
| 分子量: | 416.7 |
| 分子式: | C18H18ClMnN2O4 |
| SMILES: | [Cl-][Mn+3]12([N]3=CC4=CC=CC(OC)=C4[O-]2)[N](CC3)=CC5=CC=CC(OC)=C5[O-]1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | EUK-134 是一种合成的超氧化物歧化酶和过氧化氢酶模拟物，可保护大鼠肾脏免受缺血再灌注引起的损伤。EUK-134 是一种具有过氧化氢酶活性的超氧化物歧化酶 (SOD) 模拟物 (SODm)。EUK-134 是一种保护有丝分裂的抗氧化剂。EUK-134 作用于 H9C2 细胞，降低NF-κB表达、MDA 水平和蛋白质羰基化。 |
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Baker, K., Marcus, C.B., Huffman, K., et al.Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: A key role for reactive oxygen species in ischemic brain injuryJ. Pharmacol. Exp. Ther.284(1),215-221(1998)
Rong, Y., Doctrow, S.R., Tocco, G., et al.EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathologyProc. Natl. Acad. Sci. USA96,9897-9902(1999)
