IKK2-IN-3
Cat. No.：YN410182
| 产品名称: | IKK2-IN-3 |
| CAS No.: | 916985-21-2 |
| Chemical Name: | 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[4-(methylsulfonyl)phenyl]methoxy]-2-thiophenecarboxamide |
| Synonyms: | CAY10575; CAY-10575; CAY 10575. |
| 分子量: | 487.6 |
| 分子式: | C22H21N3O6S2 |
| SMILES: | COc1cc2c(ncn2c2cc(OCc3ccc(cc3)S(=O)(=O)C)c(s2)C(=O)N)cc1OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | IKK2-IN-3 (Compound 8) 是一种IKK2抑制剂，IC50为 0.075 μM。 |
| IC50和靶点: | [{name:"IKK2:0.075 μM (IC50)"}] |
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| Solvent & Solubility: |
Bamborough, P., Christopher, J.A., Cutler, G.J., et al.5-(1H-benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinaseBioorg. Med. Chem. Lett.16(24),6236-6240(2006)
Xie, H.-Z., Liu, L.-Y., Ren, J.-X., et al.Pharmacophore modeling and hybrid virtual screening for the discovery of novel IκB kinase 2 (IKK2) inhibitorsJ. Biomol. Struct. Dyn.29(1),165-179(2011)
Al-Ali, H., Schürer, S.C., Lemmon, V.P., et al.Chemical interrogation of the neuronal kinome using a primary cell-based screening assayACS Chem. Biol.8(5),1027-1036(2013)
