ML334
Cat. No.：YN410016
CAS No. ：1432500-66-7
| 产品名称: | ML334 |
| CAS No.: | 1432500-66-7 |
| Chemical Name: | (1S,2R)-2-[[(1S )-1-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]-3,4-dihydro-2(1H)-isoquinolinyl]carbonyl]-cyclohexanecarboxylic acid |
| Synonyms: | LH601A |
| 分子量: | 446.50 |
| 分子式: | C₂₆H₂₆N₂O₅ |
| SMILES: | O=C(C1=CC=CC=C1C2=O)N2C[C@@H]3C4=CC=CC=C4CCN3C([C@H]5[C@H](CCCC5)C(O)=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ML334 (LH601A) 是一种有效的，细胞可渗透的NRF2激活剂，通过抑制Keap1-NRF2蛋白质相互作用来发挥作用。ML334 以Kd值为 1μM 来结合 Keap1 Kelch 域。ML334 刺激NRF2表达和核易位并诱导抗氧化反应元件 (ARE) 活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Hu, L., Magesh, S., Chen, L., et al.Discovery of a small-molecule inhibitor and cellular probe of Keap1-Nrf2 protein-protein interactionBioorg. Med. Chem. Lett.23(10),3039-3043(2013)
