Bardoxolone methyl
Cat. No.：YN410047
CAS No. ：218600-53-4
| 产品名称: | Bardoxolone methyl |
| CAS No.: | 218600-53-4 |
| Chemical Name: | 2-cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid, methyl ester |
| Synonyms: | 甲基巴多索隆; RTA 402; NSC 713200; CDDO Methyl ester |
| 分子量: | 505.69 |
| 分子式: | C₃₂H₄₃NO₄ |
| SMILES: | O=C1C(C#N)=C[C@@]2(C)[C@](CC[C@]([C@@]3(C)[C@@]4([H])[C@@]5([H])[C@@](CCC(C)(C)C5)(C(OC)=O)CC3)(C)C2=CC4=O)([H])C1(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bardoxolone methyl (NSC 713200; RTA 402; CDDO Methyl ester) 是一种合成的三萜类化合物，具有潜在的抗肿瘤和抗炎活性，作为Nrf2通路的激活剂和NF-κB途径的抑制剂。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Honda, T., Honda, Y., Favaloro, F.G., Jr., et al.A novel dicyanotriterpenoid, 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-onitrile, active at picomolar concentrations for inhibition of nitric oxide productionBioorg. Med. Chem. Lett.12(7),1027-1030(2002)
Sporn, M.B., Liby, K.T., Yore, M.M., et al.New synthetic triterpenoids: Potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stressJ. Nat. Prod.74(3),537-545(2011)
Konopleva, M., Tsao, T., Ruvolo, P., et al.Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemiaBlood99(1),326-335(2002)
Shishodia, S., Sethi, G., Konopleva, M., et al.A synthetic triterpenoid, CDDO-Me, inhibits IκBα kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor κB-regulated gene products in human leukemic cellsClin. Cancer Res.12(6),1828-1838(2006)
Saha, P.K., Reddy, V.T., Konopleva, M., et al.The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Leprdb/db miceJ. Biol. Chem.285(52),40581-40592(2010)
