Sulforaphane
Cat. No.：YN410055
CAS No. ：4478-93-7
| 产品名称: | Sulforaphane |
| CAS No.: | 4478-93-7 |
| Chemical Name: | 1-isothiocyanato-4-(methylsulfinyl)-butane |
| Synonyms: | 萝卜硫素 |
| 分子量: | 177.29 |
| 分子式: | C₆H₁₁NOS₂ |
| SMILES: | O=S(CCCCN=C=S)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Sulforaphane 是存在于多种蔬菜中的天然异硫氰酸酯。Sulforaphane 增加肿瘤抑制蛋白的转录并抑制组蛋白脱乙酰酶的活性。Sulforaphan 可以激活Nrf2，并通过 AMPK 依赖性信号传导抑制高糖诱导的胰腺癌。 Sulforaphan 具有抗癌和抗炎活性。 |
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Gao, L., Wang, J., Sekhar, K.R., et al.Novel n-3 fatty acid oxidation products activate Nrf2 by destabilizing the association between Keap1 and Cullin3J. Biol. Chem.282(4),2529-2537(2007)
Taguchi, K., Motohashi, H., and Yamamoto, M.Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolutionGenes Cells16(2),123-140(2011)
Dinkova-Kostova, A.T., Holtzclaw, W.D., Cole, R.N., et al.Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidantsProc. Natl. Acad. Sci. USA99(18),11908-11913(2012)
Clarke, J.D., Hsu, A., Yu, Z., et al.Differential effects of sulforaphane on histone deacetylases, cell cycle arrest and apoptosis in normal prostate cells versus hyperplastic and cancerous prostate cellsMol. Nutr. Food Res.55(7),999-1009(2011)
