Bardoxolone
Cat. No.：YN410066
CAS No. ：218600-44-3
| 产品名称: | Bardoxolone |
| CAS No.: | 218600-44-3 |
| Chemical Name: | 2-cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid |
| Synonyms: | CDDO; RTA 401 |
| 分子量: | 491.66 |
| 分子式: | C₃₁H₄₁NO₄ |
| SMILES: | CC1(C)CC[C@@]2(C(O)=O)[C@@]([C@](C(C=C3[C@@]4(C)CC[C@]5([H])[C@]3(C)C=C(C#N)C(C5(C)C)=O)=O)([H])[C@@]4(C)CC2)([H])C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Bardoxolone 是一种 新型核调节因子 (Nrf-2)激活剂。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Honda, T., Rounds, B.V., Gribble, G.W., et al.Design and synthesis of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, a novel and highly active inhibitor of nitric oxide production in mouse macrophagesBioorg. Med. Chem. Lett.8,2711-2714(1998)
Suh, N., Wang, Y., Honda, T., et al.A novel synthetic oleanane triterpenoid, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid, with potent differentiating, antiproliferative, and anti-inflammatory activityCancer Res.59,336-341(1999)
Ferguson, H.E., Kulkarni, A., Lehmann, G.M., et al.Electrophilic peroxisome proliferator-activated receptor-γ ligands have potent antifibrotic effects in human lung fibroblastsAm. J. Respir. Cell Mol. Biol.41,722-730(2009)
Liby, K., Hock, T., Yore, M.M., et al.The synthetic triterpenoids, CDDO and CDDO-imidazolide, are potent inducers of heme oxygenase-1 and Nrf2/ARE signalingCancer Res.65(11),4789-4798(2005)
Fourtounis, J., Wang, I.M., Mathieu, M.C., et al.Gene expression profiling following NRF2 and KEAP1 siRNA knockdown in human lung fibroblasts identifies CCL11/Eotaxin-1 as a novel NRF2 regulated geneRespir. Res.13(1),(2012)
