Brusatol
Cat. No.：YN410079
| 产品名称: | Brusatol |
| CAS No.: | 14907-98-3 |
| Chemical Name: | 13,20-epoxy-3,11β,12α-trihydroxy-15β-[(3-methyl-1-oxo-2-buten-1-yl)oxy]-2,16-dioxo-picras-3-en-21-oic acid, methyl ester |
| Synonyms: | 鸦胆子苦醇; NSC 172924 |
| 分子量: | 520.53 |
| 分子式: | C₂₆H₃₂O₁₁ |
| SMILES: | CC([C@](C[C@@](O1)2[H])3[H])=C(O)C(C[C@]3(C)[C@]4([H])[C@]2(CO[C@@]5([C@@H](O)[C@@H]4O)C(OC)=O)[C@@]5([H])[C@@H](OC(/C=C(C)/C)=O)C1=O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Brusatol (NSC 172924)，从Brucea javanica植物中分离的，可抑制Nrf2。 |
| IC50和靶点: | |
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Lee, K.-H., Tani, S., and Imakura, Y.Antimalarial agents, 4. Synthesis of a brusatol analog and biological activity of brusatol-related compoundsJ. Nat. Prod.50(5),847-851(1987)
Lahrita, L., Moriai, K., Iwata, R., et al.Quassinoids in Brucea javanica are potent stimulators of lipolysis in adipocytesFitoterapia137,104250(2019)
Ren, D., Villeneuve, N.F., Jiang, T., et al.Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanismProc. Natl. Acad. Sci. USA108(4),1433-1438(2011)
Zhou, J., Wang, T., Dou, Y., et al.Brusatol ameliorates 2, 4, 6-trinitrobenzenesulfonic acid-induced experimental colitis in rats: Involvement of NF-κB pathway and NLRP3 inflammasomeInt. Immunopharmacol.64,264-274(2018)
