Curcumin
Cat. No.：YN410088
| 产品名称: | Curcumin |
| CAS No.: | 458-37-7 |
| Chemical Name: | 1,7-bis(4-hydroxy-3-methoxyphenyl)-1E,6E-heptadiene-3,5-dione |
| Synonyms: | 姜黄素; Diferuloylmethane; Natural Yellow 3; Turmeric yellow |
| 分子量: | 368.38 |
| 分子式: | C₂₁H₂₀O₆ |
| SMILES: | O=C(CC(/C=C/C1=CC=C(O)C(OC)=C1)=O)/C=C/C2=CC=C(O)C(OC)=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Curcumin (Diferuloylmethane)，是一种天然酚类化合物，是乙酰转移酶p300/CREB 结合蛋白特异性抑制剂，抑制组蛋白/非组蛋白的乙酰化和组蛋白乙酰转移酶依赖的染色质转录。Curcumin 对NF-κb和MAPKs有抑制作用，并具有抗炎、抗氧化、抗增殖和抗血管生成等多种药理作用。Curcumin 通过 Keap1 半胱氨酸修饰诱导 Nrf2 蛋白的稳定。 |
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Brouet, I., and Ohshima, H.Curcumin, an anti-tumor promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophagesBiochem. Biophys. Res. Commun.206,533-540(1995)
Zhang, N., Li, H., Jia, J., et al.Anti-inflammatory effect of curcumin on mast cell-mediated allergic responses in ovalbumin-induced allergic rhinitis mouseCell. Immunol.298(1-2),88-95(2015)
Conney, A.H., Lysz, T., Ferraro, T., et al.Inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skinAdv. Enzyme Regul.31,385-396(1991)
Tanaka, T., Makita, H., Ohnishi, M., et al.Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by dietary curcumin and hesperidin: Comparison with the protective effect of β-caroteneCancer Res.54,4653-4659(1994)
