IC87201
Cat. No.：YN360033
| 产品名称: | IC87201 |
| CAS No.: | 866927-10-8 |
| Chemical Name: | 2-[(1H-benzotriazol-6-ylamino)methyl]-4,6-dichloro-phenol |
| Synonyms: | IC87201;IC 87201 |
| 分子量: | 309.15 |
| 分子式: | C₁₃H₁₀Cl₂N₄O |
| SMILES: | OC1=C(Cl)C=C(Cl)C=C1CNC2=CC=C3N=NNC3=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | IC87201 是 PSD95-nNOS 相互作用的抑制剂，可抑制nMDAR诱导的一氧化氮和 cGMP 的形成。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Florio, S.K., Loh, C., Huang, S.M., et al.Disruption of nNOS-PSD95 protein-protein interaction inhibits acute thermal hyperalgesia and chronic mechanical allodynia in rodentsBr. J. Pharmacol.158(2),494-506(2009)
Hu, W., Guan, L.-S., Dang, X.-B., et al.Small-molecule inhibitors at the PSD-95/nNOS interface attenuate MPP+-induced neuronal injury through Sirt3 mediated inhibition of mitochondrial dysfunctionNeurochem. Int.79,57-64(2014)
Doucet, M.V., Levine, H., Dev, K.K., et al.Small-molecule inhibitors at the PSD-95/nNOS interface have antidepressant-like properties in miceNeuropsychopharmacology38(8),1575-1584(2013)
