(R)-Serine
Cat. No.：YN360053
| 产品名称: | (R)-Serine |
| CAS No.: | 312-84-5 |
| Chemical Name: | (R)-2-Amino-3-hydroxypropanoic Acid; (R)-2-Amino-3-hydroxypropanoic Acid; (R)-Serine; NSC 77689; Cycloserine Impurity 1 |
| Synonyms: | D-丝氨酸,(R)-Serine |
| 分子量: | 105.09 |
| 分子式: | C₃H₇NO₃ |
| SMILES: | N[C@H](CO)C(O)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (R)-Serine 是一种具有独特的神经递质特性的神经胶质-突触相互作用中涉及的内源性氨基酸，是NMDA谷氨酸受体的有效共激动剂。(R)-Serine 在主要的 NMDAR 依赖性过程中具有主要的调节作用，包括 NMDAR 介导的神经传递，神经毒性，突触可塑性和细胞迁移。 |
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Matsui, T., Sekiguchi, M., Hashimoto, A., et al.Functional comparison of ᴅ-serine and glycine in rodents: The effect on cloned NMDA receptors and the extracellular concentrationJ. Neurochem.65(1),454-458(1995)
Xia, M., Liu, Y., Figueroa, D.J., et al.Characterization and localization of a human serine racemaseBrain Res. Mol. Brain Res.125(1-2),96-104(2004)
Mothet, J.P., Parent, A.T., Wolosker, H., et al.ᴅ-Serine is an endogenous ligand for the glycine site of the N-methyl-ᴅ-aspartate receptorProc. Natl. Acad. Sci. USA97(9),4926-4931(2000)
Labrie, V., Fukumura, R., Rastogi, A., et al.Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse modelHum. Mol. Genet.18(17),3227-3243(2009)
Cho, S.-E., Na, K.-S., Cho, S.-J., et al.Low ᴅ-serine levels in schizophrenia: A systematic review and meta-analysisNeurosci. Lett.634,42-51(2016)
