7-Chlorokynurenic acid
Cat. No.：YN360056
CAS No. ：18000-24-3
| 产品名称: | 7-Chlorokynurenic acid |
| CAS No.: | 18000-24-3 |
| Chemical Name: | 7-chloro-4-hydroxy-2-quinolinecarboxylic acid |
| Synonyms: | 7-CKA |
| 分子量: | 223.61 |
| 分子式: | C₁₀H₆ClNO₃ |
| SMILES: | O=C(C1=NC2=CC(Cl)=CC=C2C(O)=C1)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | 7-Chlorokynurenic acid (7-CKA) 是一种有效且选择性的 N-methyl-D-aspartate (NMDA) 受体的甘氨酸 B 激动剂位点拮抗剂 (IC50=0.56 μM)。7-Chlorokynurenic acid 也是谷氨酸重摄取到突触小泡中的有效抑制剂，Ki为 0.59 μM。7-Chlorokynurenic acid 在神经传递后具有有效的镇痛作用。 |
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Kemp, J.A., Foster, A.C., Leeson, P.D., et al.7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complexProc. Natl. Acad. Sci. USA85(17),6547-6550(1988)
Ohno, M., Yamamoto, T., and Watanabe, S.Intrahippocampal administration of a glycine site antagonist impairs working memory performance of ratsEur. J. Pharmacol.253(1-2),183-187(1994)
Zhu, W.-L., Wang, S.-J., Liu, M.-M., et al.Glycine site N-methyl-D-aspartate receptor antagonist 7-CTKA produces rapid antidepressant-like effects in male ratsJ. Psychiatry Neurosci.38(5),306-316(2013)
