Memantine hydrochloride
Cat. No.：YN360776
CAS No. ：41100-52-1
| 产品名称: | Memantine hydrochloride |
| CAS No.: | 41100-52-1 |
| Chemical Name: | 3,5-dimethyl-tricyclo[3.3.1.13,7]decan-1-amine, monohydrochloride |
| Synonyms: | 盐酸美金刚; D-145 hydrochloride |
| 分子量: | 215.76 |
| 分子式: | C₁₂H₂₂ClN |
| SMILES: | N[C@@]1(C2)C[C@]3(C)C[C@@]2(C)C[C@@H](C3)C1.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Memantine (hydrochloride) (D-145 (hydrochloride)) 是金刚胺衍生物，是一种温和的 NMDA 受体 (NMDA receptor) 非竞争性拮抗剂, 能够抑制 CYP2B6 和 CYP2D6。 |
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Chen, H.S.V., Pellegrini, J.W., Aggarwal, S.K., et al.Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: Therapeutic advantage against NMDA receptor-mediated neurotoxicityJ. Neurosci.12(11),4427-4436(1992)
Wang, X., Blanchard, J., Grundke-Iqbal, I., et al.Memantine attenuates Alzheimer's disease-like pathology and cognitive impairmentPLoS One10(12),e0145441(2015)
Vangeliene, V., Olevska, A., and Spanagel, R.Long‐lasting effect of NMDA receptor antagonist memantine on ethanol‐cue association and relapseJ. Neurochem.135(6),1080-1085(2015)
Chen, Z.-Z., Yang, D.-D., Zhao, Z., et al.Memantine mediates neuroprotection via regulating neurovascular unit in a mouse model of focal cerebral ischemiaLife Sci.150,8-14(2016)
