Orphenadrine hydrochloride
Cat. No.：YN360851
| 产品名称: | Orphenadrine hydrochloride |
| CAS No.: | 341-69-5 |
| Chemical Name: | N,N-dimethyl-2-[(2-methylphenyl)phenylmethoxy]-ethanamine, monohydrochloride |
| Synonyms: | Mephenamin,盐酸邻甲苯海拉明,Mebedrol |
| 分子量: | 305.84 |
| 分子式: | C₁₈H₂₄ClNO |
| SMILES: | CC1=CC=CC=C1C(C2=CC=CC=C2)OCCN(C)C.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Orphenadrine盐酸盐是非竞争性的NMDA受体拮抗剂, Ki值 为6.0 ± 0.7 μM。 |
| IC50和靶点: | |
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Stanton, T., Bolden-Watson, C., Cusack, B., et al.Antagonism of the five cloned human muscarinic cholinergic receptors expressed in CHO-K1 cells by antidepressants and antihistaminicsBiochem. Pharmacol.45(11),2352-2354(1993)
Ban, T., and Hojo, M.A comparative study of the effects of anti-parkinson drugs on the oxotremorine-induced EEG and muscular activitiesPsychopharmacologia19(1),1-15(1971)
Kornhuber, J., Parsons, C.G., Hartmann, S., et al.Orphenadrine is an uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist: Binding and patch clamp studiesJ. Neural Transm. Gen. Sect.102(3),237-246(1995)
