Tacrine hydrochloride
Cat. No.：YN360872
| 产品名称: | Tacrine hydrochloride |
| CAS No.: | 1684-40-8 |
| Chemical Name: | 1,2,3,4-tetrahydro-9-acridinamine, monohydrochloride |
| Synonyms: | 四氢氨基吖啶,Tacrine HCl,盐酸他克林 |
| 分子量: | 234.72 |
| 分子式: | C₁₃H₁₅ClN₂ |
| SMILES: | NC1=C(CCCC2)C2=NC3=CC=CC=C31.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tacrine hydrochloride 是一种AChE和BChE的有效抑制剂，IC50值分别为 31 nM 和 25.6 nM 。Tacrine hydrochloride 也是NMDAR的抑制剂，IC50值为 26 μM。Tacrine hydrochloride 可用于研究阿尔茨海默氏症。 |
| IC50和靶点: | |
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Crismon, M.L.Pharmacokinetics and drug interactions of cholinesterase inhibitors administered in Alzheimer's diseasePharmacotherapy18(2 Pt. 2),47-54(1998)
Ahmed, M., Rocha, J.B., Corrêa, M., et al.Inhibition of two different cholinesterases by tacrineChem. Biol. Interact.162(2),165-171(2006)
Drukarch, B., Leysen, J.E., and Stoof, J.C.Further analysis of the neuropharmacological profile of 9-amino-1,2,3,4-tetrahydroacridine (THA), an alleged drug for the treatment of Alzheimer's diseaseLife Sci.42(9),1011-1017(1988)
McKenna, M.T., Proctor, G.R., Young, L.C., et al.Novel tacrine analogues for potential use against Alzheimer's disease: Potent and selective acetylcholinesterase inhibitors and 5-HT uptake inhibitorsJ. Med. Chem.40(22),3516-3523(1997)
Dolezal, V., Lisá, V., and Tucek, S.Effect of tacrine on intracellular calcium in cholinergic SN56 neuronal cellsBrain Res.769(2),219-224(1997)
Giacobini, E.Cholinesterase inhibitors for Alzheimer's disease therapy: From tacrine to future applicationsNeurochem Int.32(5-6),413-419(1998)
