TBCA
Cat. No.：YN450033
CAS No. ：934358-00-6
规格
价格(RMB)
库存
| 产品名称: | TBCA |
| CAS No.: | 934358-00-6 |
| Chemical Name: | (2E)-3-(2,3,4,5-tetrabromophenyl)-2-propenoic acid |
| Synonyms: | Casein Kinase II Inhibitor III, TBCA |
| 分子量: | 463.74 |
| 分子式: | C₉H₄Br₄O₂ |
| SMILES: | OC(/C=C/C1=C(C(Br)=C(Br)C(Br)=C1)Br)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TBCA 是一种高选择性的酪蛋白激酶IICK2抑制剂，IC50为 110 nM，Ki为 77 nM。TBCA 对 CK1、DYRK1A 和 其它 27 个激酶表现出选择性。 |
| IC50和靶点: | [{name:"CK2:110 nM (IC50)"},{name: "CK2:77 nM (Ki)"}] |
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| Solvent & Solubility: |
López-Ramos, M., Prudent, R., Moucadel, V., et al.New potent dual inhibitors of CK2 and Pim kinases: Discovery and structural insightsFASEB J.24(9),3171-3185(2010)
Pagano, M.A., Cesaro, L., Meggio, F., et al.Protein kinase CK2: A newcomer in the 'druggable kinome'Biochem. Soc. Trans.34(Pt 6),1303-1306(2006)
Pagano, M.A., Poletto, G., Di Maira, G., et al.Tetrabromocinnamic acid (TBCA) and related compounds represent a new class of specific protein kinase CK2 inhibitorsChembiochem8(1),129-139(2007)
Ryu, S.Y., and Kim, S.Evaluation of CK2 inhibitor (E)-3-(2,3,4,5-tetrabromophenyl)acrylic acid (TBCA) in regulation of platelet functionEur. J. Pharmacol.720(1-3),391-400(2013)
Kim, H., Choi, K., Kang, H., et al.Identification of a novel function of CX-4945 as a splicing regulatorPLoS One9(4),e94978(2014)
