PF-4800567
Cat. No.：YN450058
CAS No. ：1188296-52-7
规格
价格(RMB)
库存
| 产品名称: | PF-4800567 |
| CAS No.: | 1188296-52-7 |
| Chemical Name: | 3-[(3-chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| Synonyms: | PF 4800567,PF-4800567 |
| 分子量: | 359.81 |
| 分子式: | C₁₇H₁₈ClN₅O₂ |
| SMILES: | NC1=C2C(N(C3CCOCC3)N=C2COC4=CC=CC(Cl)=C4)=NC=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PF-4800567 是一种有效、选择性的酪蛋白激酶 1ϵ (CK1ϵ) 抑制剂，IC50值为 32 nM，对其选择性是对 CK1δ (IC50，711 nM) 的 20 倍。 |
| IC50和靶点: | [{name:"CKIδ:711 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Walton, K.M., Fisher, K., Rubitski, D., et al.Selective inhibition of casein kinase 1ε minimally alters circadian clock periodJ. Pharmacol. Exp. Ther.330(2),430-439(2009)
Meng, Q.J., Maywood, E.S., Bechtold, D.A., et al.Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymesProc. Natl. Acad. Sci. USA107(34),15240-15245(2016)
Perez, D.I., Gil, C., and Martinez, A.Protein kinases CK1 and CK2 as new targets for neurodegenerative diseasesMed. Res. Rev.31(6),924-954(2011)
