IC261
Cat. No.：YN450063
CAS No. ：186611-52-9
规格
价格(RMB)
库存
| 产品名称: | IC261 |
| CAS No.: | 186611-52-9 |
| Chemical Name: | 1,3-dihydro-3-[(2,4,6-trimethoxyphenyl)methylene]-2H-indol-2-one |
| Synonyms: | SU-5607 |
| 分子量: | 311.33 |
| 分子式: | C₁₈H₁₇NO₄ |
| SMILES: | O=C1NC2=C(C=CC=C2)/C1=C\C3=C(OC)C=C(OC)C=C3OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | IC261 是一种选择性的，ATP 竞争性的CK1抑制剂，对Ckiδ，Ckiε和 Ckiα1 的IC50值分别为 1 μM，1 μM 和 16 μM。 |
| IC50和靶点: | [{name:"CKIδ:1 μM (IC50)"},{name: "CkIα1:16 μM (IC50)"}] |
| In Vitro: | |
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| Clinical Trial: | |
| Solvent & Solubility: |
Mashhoon, N., DeMaggio, A.J., Tereshko, V., et al.Crystal structure of a conformation-selective casein kinase-1 inhibitorJ. Biol. Chem.275(26),20052-20060(2000)
Behrend, L., Milne, D.M., Stöter, M., et al.IC261, a specific inhibitor of the protein kinases casein kinase 1-delta and -epsilon, triggers the mitotic checkpoint and induces p53-dependent postmitotic effectsOncogene19(47),5303-5313(2000)
van Ooijen, G., Martin, S.F., Barrios-Llerena, M.E., et al.Functional analysis of the rodent CK1tau mutation in the circadian clock of a marine unicellular algaBMC Cell Biol.14,(2013)
Rachidi, N., Taly, J.F., Durieu, E., et al.Pharmacological assessment defines Leishmania donovani casein kinase 1 as a drug target and reveals important functions in parasite viability and intracellular infectionAntimicrob. Agents Chemother.58(3),1501-1515(2014)
Kurihara, T., Sakurai, E., Toyomoto, M., et al.Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitorsMol. Pain10,(2014)
