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IWP-2

Cat. No.:YN450088

  • CAS No. :686770-61-6

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    • 产品名称: IWP-2
      CAS No.: 686770-61-6
      Chemical Name: N-(6-methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-4-oxo-3-phenylthieno[3,2-d]pyrimidin-2-yl)thio]-acetamide
      Synonyms:IWP2
      分子量:466.60
      分子式:C₂₂H₁₈N₄O₂S₃
      SMILES:O=C(NC1=NC2=CC=C(C)C=C2S1)CSC3=NC(CCS4)=C4C(N3C5=CC=CC=C5)=O
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: IWP-2 是Wnt加工和分泌的抑制剂,其IC50为 27 nM。IWP-2 靶向膜结合的 O-酰基转移酶 porcupine (Porcn),从而阻止关键的 Wnt 配体棕榈糖基化。IWP-2 还是一种具有 ATP 竞争能力的CK1δ抑制剂,对于M82FCK1δ的IC50为 40 nM。
      IC50和靶点: [{name:"CK1δ:40 nM (IC50)"}]
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    • Clevers, H.Wnt/β-catenin signaling in development and diseaseCell127(3),469-480(2006)

      Polakis, P.Wnt signaling and cancerGenes Dev.14(15),1837-1851(2000)

      Reya, T., and Clevers, H.Wnt signalling in stem cells and cancerNature434(7035),834-850(2005)

      Chen, B., Dodge, M.E., Tang, W., et al.Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancerNat. Chem. Biol.5(2),100-107(2009)

      Lian, X., Hsiao, C., Wilson, G., et al.Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signalingProc. Natl. Acad. Sci. USA,E1848-E1857(2012)

      Mo, M.L., Li, M.R., Chen, Z., et al.Inhibition of the Wnt palmitoyltransferase porcupine suppresses cell growth and downregulates the Wnt/ß-catenin pathway in gastric cancerOncol. Lett.5(5),1719-1723(2013)

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