Emodin
Cat. No.：YN450089
CAS No. ：518-82-1
规格
价格(RMB)
库存
| 产品名称: | Emodin |
| CAS No.: | 518-82-1 |
| Chemical Name: | 1,3,8-trihydroxy-6-methyl-9,10-anthracenedione |
| Synonyms: | 大黄素; Frangula emodin |
| 分子量: | 270.24 |
| 分子式: | C₁₅H₁₀O₅ |
| SMILES: | O=C1C2=C(C=C(C)C=C2O)C(C3=CC(O)=CC(O)=C31)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Emodin (Frangula emodin) 是一种广谱抗癌剂。Emodin 抑制蛋白激酶CKII活性，IC50为 2 μM。Emodin 抑制 SARS 冠状病毒 (SARS-CoV)。 |
| IC50和靶点: | |
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Tzeng, T.F., Lu, H.J., Liou, S.S., et al.Emodin, a naturally occurring anthraquinone derivative, ameliorates dyslipidemia by activating AMP-activated protein kinase in high-fat-diet-fed ratsEvid. Based Complement. Alternat. Med.,781812(2012)
Alisi, A., Pastore, A., Ceccarelli, S., et al.Emodin prevents intrahepatic fat accumulation, inflammation and redox status imbalance during diet-induced hepatosteatosis in ratsInt. J. Mol. Sci.13(2),2276-2289(2012)
Lin, S.Z., Wei, W.T., Chen, H., et al.Antitumor activity of emodin against pancreatic cancer depends on its dual role: Promotion of apoptosis and suppression of angiogenesisPLoS One7(8),1-15(2012)
Sarno, S., De Moliner, E., Ruzzene, M., et al.Biochemical and three-dimensional-structural study of the specific inhibition of protein kinase CK2 by [5-oxo-5,6-dihydroindolo-(1,2-a)quinazolin-7-yl]acetic acid (IQA)Biochem. J.374(Pt 3),639-646(2003)
Füllbeck, M., Huang, X., Dumdey, R., et al.Novel curcumin- and emodin-related compounds identified by in silico 2D/3D conformer screening induce apoptosis in tumor cellsBMC Cancer5(97),1-14(2005)
Matsuda, H., Shimoda, H., Morikawa, T., et al.Phytoestrogens from the roots of Polygonum cuspidatum (Polygonaceae): Structure-requirement of hydroxyanthraquinones for estrogenic activityBioorg. Med. Chem. Lett.11(14),1839-1842(2001)
