TBB
Cat. No.：YN450090
CAS No. ：17374-26-4
规格
价格(RMB)
库存
| 产品名称: | TBB |
| CAS No.: | 17374-26-4 |
| Chemical Name: | 4,5,6,7-tetrabromo-1H-benzotriazole |
| Synonyms: | NSC 231634; Casein Kinase II Inhibitor I |
| 分子量: | 434.71 |
| 分子式: | C₆HBr₄N₃ |
| SMILES: | BrC1=C2C(NN=N2)=C(Br)C(Br)=C1Br |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TBB是可渗透细胞，ATP竞争型的CK2抑制剂，抑制大鼠肝脏CK2的IC50值为0.15 μM。 |
| IC50和靶点: | [{name:"CK2:0.15 μM (IC50, Human CK2)"},{name: "PIM1:1.04 μM (IC50)"},{name: "PIM2:4.3 μM (IC50)"},{name: "PIM3:0.86 μM (IC50)"},{name: "HIPK2:5.3 μM (IC50)"},{name: "HIPK3:4.9 μM (IC50)"},{name: "DYRK1a:4.36 μM (IC50)"},{name: "DYRK2:0.99 μM (IC50)"},{name: "DYRK3:5.3 μM (IC50)"},{name: "PKD1:5.9 μM (IC50)"},{name: "CDK2:14 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Sarno, S., Reddy, H., Meggio, F., et al.Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2')FEBS Lett.496(1),44-48(2001)
Pagano, M.A., Bain, J., Kazimierczuk, Z., et al.The selectivity of inhibitors of protein kinase CK2: An updateBiochem. J.415(3),353-365(2008)
