PF-670462
Cat. No.：YN450101
CAS No. ：950912-80-8
规格
价格(RMB)
库存
| 产品名称: | PF-670462 |
| CAS No.: | 950912-80-8 |
| Chemical Name: | 4-[1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-2-pyrimidinamine, dihydrochloride |
| Synonyms: | PF670462 |
| 分子量: | 410.32 |
| 分子式: | C₁₉H₂₂Cl₂FN₅ |
| SMILES: | NC1=NC=CC(C2=C(C3=CC=C(F)C=C3)N=CN2C4CCCCC4)=N1.[H]Cl.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PF-670462 是一种有效的，选择性的casein kinase (CKIε/CKIδ)抑制剂，IC50值分别为 7.7 nM 和 14 nM。 |
| IC50和靶点: | [{name:"CKIδ:14 nM (IC50)"},{name: "EGFR:150 nM (IC50)"},{name: "SAPK2A/p38:190 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
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Bryant, C.D., Graham, M.E., Distler, M.G., et al.A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetaminePsychopharmacology (Berl)203(4),703-711(2009)
Badura, L., Swanson, T., Adamowicz, W., et al.An inhibitor of casein kinase Iε induces phase delays in circadian rhythms under free-running and entrained conditionsJ. Pharmacol. Exp. Ther.322(2),730-738(2007)
Storz, S.S., Tovin, A., Mracek, P., et al.Casein kinase 1δ activity: A key element in the zebrafish circadiam timing systemPLoS One8(1),1-10(2013)
