DMAT
Cat. No.：YN450102
CAS No. ：749234-11-5
规格
价格(RMB)
库存
| 产品名称: | DMAT |
| CAS No.: | 749234-11-5 |
| Chemical Name: | 4,5,6,7-tetrabromo-N,N-dimethyl-1H-benzimidazol-2-amine |
| Synonyms: | CK2 Inhibitor; Casein kinase II Inhibitor |
| 分子量: | 476.79 |
| 分子式: | C₉H₇Br₄N₃ |
| SMILES: | CN(C)C1=NC2=C(Br)C(Br)=C(Br)C(Br)=C2N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | DMAT 是一种有效的，特异性的CK2抑制剂，IC50值为 130 nM。 |
| IC50和靶点: | [{name:"CK2:0.13 μM (IC50, Human CK2)"},{name: "PIM1:0.148 μM (IC50)"},{name: "PIM2:1.6 μM (IC50)"},{name: "PIM3:0.097 μM (IC50)"},{name: "HIPK2:0.37 μM (IC50)"},{name: "HIPK3:0.59 μM (IC50)"},{name: "DYRK1a:0.41 μM (IC50)"},{name: "DYRK2:0.35 μM (IC50)"},{name: "DYRK3:1.7 μM (IC50)"},{name: "PKD1:0.18 μM (IC50)"},{name: "CDK2:0.64 μM (IC50)"}] |
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Pagano, M.A., Bain, J., Kazimierczuk, Z., et al.The selectivity of inhibitors of protein kinase CK2: An updateBiochem. J.415(3),353-365(2008)
Lawnicka, H., Kowalewicz-Kulbat, M., Sicinska, P., et al.Anti-neoplastic effect of protein kinase CK2 inhibitor, 2-dimethylamino-4,5,6,7-tetrabromobenzimidazole (DMAT), on growth and hormonal activity of human adrenocortical carcinoma cell line (H295R) in vitroCell Tissue Res.340(2),371-379(2010)
Sass, G., Klinger, N., Surma, H., et al.Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMATInt. J. Oncol.39(2),433-442(2011)
Yde, C.W., Frogne, T., Lykkesfeldt, A.E., et al.Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMATCancer Lett.256(2),229-237(2007)
