Blarcamesine
Cat. No.：YN320283
| 产品名称: | Blarcamesine |
| CAS No.: | 195615-83-9 |
| Chemical Name: | tetrahydro-N,N-dimethyl-2,2-diphenyl-3-furanmethanamine |
| Synonyms: | AVex-73; AE-37 |
| 分子量: | 281.39 |
| 分子式: | C₁₉H₂₃NO |
| SMILES: | CN(C)CC1C(C2=CC=CC=C2)(C3=CC=CC=C3)OCC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Blarcamesine (AVex-73;AE-37) 是一种Sigma-1 受体激动剂和毒蕈碱受体 (muscarinic receptor) 调节剂，具有抗惊厥、抗失忆、神经保护和抗抑郁的特性。Blarcamesine 能改善 Rett 综合征小鼠模型的神经功能损害。 |
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Lahmy, V., Long, R.M., Morin, D., et al.Mitochondrial protection by the mixed muscarinic/σ1 ligand ANAVEX2-73, a tetrahydrofuran derivative, in Aβ25-35 peptide-injected mice, a nontransgenic Alzheimer's disease modelFront. Cell. Neurosci.8,463(2015)
Lahmy, V., Meunier, J., Malström, S., et al.Blockade of Tau hyperphosphorylation and Aβ1-42 generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and σ1 receptor agonist, in a nontransgenic mouse model of Alzheimer's diseaseNeuropsychopharmacology38(9),17061723(2013)
Kaufmann, W., Sprouse, J., Rebowe, N., et al.ANAVEX®2-73 (blarcamesine), a Sigma-1 receptor agonist, ameliorates neurologic impairments in a mouse model of Rett syndromePharmacol. Biochem. Behav.187,172796(2019)
