RHC 80267
Cat. No.：YN320320
CAS No. ：83654-05-1
| 产品名称: | RHC 80267 |
| CAS No.: | 83654-05-1 |
| Chemical Name: | 1,1’-[O,O’-[1,6-hexanediylbis(iminocarbonyl)]dioxime] |
| Synonyms: | U-57908 |
| 分子量: | 394.51 |
| 分子式: | C₂₀H₃₄N₄O₄ |
| SMILES: | O=C(O/N=C1CCCCC\1)NCCCCCCNC(O/N=C2CCCCC/2)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | RHC 80267 (U-57908) 是一种有效的选择性二酰基甘油脂酶(DAGL)抑制剂 (对犬血小板的IC50为 4 μM)。RHC 80267 抑制胆碱酯酶活性，IC50为 4 μM，从而增强了乙酰胆碱引起的松弛。RHC 80267 还抑制COX活性和磷脂酰胆碱的水解。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Sutherland, C.A., and Amin, D.Relative activities of rat and dog platelet phospholipase A2 and diglyceride lipase. Selective inhibition of diglyceride lipase by RHC 80267J. Biol. Chem.257(23),14006-14010(2014)
Hoover, H.S., Blankman, J.L., Niessen, S., et al.Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profilingBioorg. Med. Chem. Lett.18(22),5838-5841(2008)
Ghisdal, P., Vandenberg, G., Hamaide, M.-C., et al.The diacylglycerol lipase inhibitor RHC-80267 potentiates the relaxation to acetylcholine in rat mesenteric artery by anti-cholinesterase actionEur. J. Pharmacol.517(1-2),97-102(2005)
