VU0119498
Cat. No.：YN320490
CAS No. ：79183-37-2
| 产品名称: | VU0119498 |
| CAS No.: | 79183-37-2 |
| Chemical Name: | 1-[(4-bromophenyl)methyl]-1H-indole-2,3-dione |
| Synonyms: | VU0119498, VU 0119498, VU-0119498 |
| 分子量: | 316.15 |
| 分子式: | C₁₅H₁₀BrNO₂ |
| SMILES: | O=C1N(C2=C(C1=O)C=CC=C2)CC3=CC=C(C=C3)Br |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | VU0119498 是一种泛 GqmAChR M1，M3，M5的正变构调节剂 (PAM)，EC50值分别为 6.04，6.38 和 4.08 µM。VU0119498 具有抗糖尿病活性。 |
| IC50和靶点: | |
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Bridges, T.M., Marlo, J.E., Niswender, C.M., et al.Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatinsJ. Med. Chem.52(11),3445-3448(2009)
Zhu, L., Rossi, M., Cohen, A., et al.Allosteric modulation of β-cell M3 muscarinic acetylcholine receptors greatly improves glucose homeostasis in lean and obese miceProc. Natl. Acad. Sci. U.S.A.116(37),18684-18690(2019)
