Umeclidinium bromide
Cat. No.：YN320541
CAS No. ：869113-09-7
| 产品名称: | Umeclidinium bromide |
| CAS No.: | 869113-09-7 |
| Chemical Name: | 4-(hydroxydiphenylmethyl)-1-[2-(phenylmethoxy)ethyl]-1-azoniabicyclo[2.2.2]octane, monobromide |
| Synonyms: | 芜地溴铵; GSK573719A |
| 分子量: | 508.49 |
| 分子式: | C₂₉H₃₄BrNO₂ |
| SMILES: | OC(C12CC[N+](CC2)(CCOCC3=CC=CC=C3)CC1)(C4=CC=CC=C4)C5=CC=CC=C5.[Br-] |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Umeclidinium bromide 是一种mAChR拮抗剂。Umeclidinium bromide 作用于克隆的人 M1-M5 mAChRs，Ki为 0.05 到 0.16 nM。 |
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Lainé, D.I., McCleland, B., Thomas, S., et al.Discovery of novel 1-azoniabicyclo[2.2.2]octane muscarinic acetylcholine receptor antagonistsJ. Med. Chem.52(8),2493-2505(2009)
Salmon, M., Luttmann, M.A., Foley, J.J., et al.Pharmacological characterization of GSK573719 (umeclidinium): A novel, long-acting, inhaled antagonist of the muscarinic cholinergic receptors for treatment of pulmonary diseasesJ. Pharmacol. Exp. Ther.345(2),260-270(2013)
Shaikh, N., Johnson, M., Hall, D.A., et al.Intracellular interactions of umeclidinium and vilanterol in human airway smooth muscleInt. J. Chron. Obstruct. Pulmon. Dis.12,1903-1913(2017)
