VU 0238429
Cat. No.：YN320553
CAS No. ：1160247-92-6
| 产品名称: | VU 0238429 |
| CAS No.: | 1160247-92-6 |
| Chemical Name: | 1-[(4-methoxyphenyl)methyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione |
| Synonyms: | VU0238429,SCR-1481B1 |
| 分子量: | 351.28 |
| 分子式: | C₁₇H₁₂F₃NO₄ |
| SMILES: | O=C1N(CC2=CC=C(OC)C=C2)C3=C(C=C(OC(F)(F)F)C=C3)C1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | VU 0238429 是mAChR M5的正变构调节剂，其EC50值为 1.16 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Bridges, T.M., Marlo, J.E., Niswender, C.M., et al.Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatinsJ. Med. Chem.52(11),3445-3448(2009)
Cieślik, P., Woźniak, M., Tokarski, K., et al.Simultaneous activation of muscarinic and GABAB receptors as a bidirectional target for novel antipsychoticsBehav. Brain Res.359,671-685(2019)
