Clozapine
Cat. No.：YN320875
| 产品名称: | Clozapine |
| CAS No.: | 5786-21-0 |
| Chemical Name: | 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine; |
| Synonyms: | 氯氮平; HF 1854 |
| 分子量: | 326.82 |
| 分子式: | C₁₈H₁₉ClN₄ |
| SMILES: | CN1CCN(CC1)C2=NC3=CC(Cl)=CC=C3NC4=CC=CC=C42 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Clozapine (HF 1854) 是用于研究精神分裂症的抗精神病药。Clozapine 是多巴胺和许多其他受体的有效拮抗剂，结合毒蕈碱M1受体的Ki值为 9.5 nM。Clozapine 也是选择性的毒蕈碱M4受体的激动剂 (EC50=11 nM)。 |
| IC50和靶点: | [{name:"5-HT2A Receptor:4 nM (Ki, Inhibitor)'}, '5-HT6 Receptor', '5-HT7 Receptor', {'mAChR1:9.5 nM (Ki, Antagonist)"},{name: "mAChR4:11 nM (EC50, Agonist)"},{name: "α2-adrenergic receptor:51 nM (Ki, Inhibitor)"},{name: "D2 Receptor:75 nM (Ki, Antagonist)"}] |
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| Solvent & Solubility: |
Millan, M.J.Improving the treatment of Schizophrenia: Focus on serotonin (5-HT)1A receptorsJ. Pharmacol. Exp. Ther.295(3),853-861(2000)
