Revefenacin
Cat. No.：YN321038
CAS No. ：864750-70-9
| 产品名称: | Revefenacin |
| CAS No.: | 864750-70-9 |
| Chemical Name: | N-[1,1′-biphenyl]-2-yl-carbamic acid, 1-[2-[[4-[[4-(aminocarbonyl)-1-piperidinyl]methyl]benzoyl]methylamino]ethyl]-4-piperidinyl ester |
| Synonyms: | TD-4208; GSK1160724 |
| 分子量: | 597.75 |
| 分子式: | C₃₅H₄₃N₅O₄ |
| SMILES: | O=C(OC1CCN(CCN(C(C2=CC=C(CN3CCC(C(N)=O)CC3)C=C2)=O)C)CC1)NC4=CC=CC=C4C5=CC=CC=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Revefenacin (TD-4208;GSK1160724) 是有效的mAChR拮抗剂，在M3受体上具有高亲和力，Ki值为0.18 nM。 |
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Hegde, S.S., Pulido-Rios, M.T., Luttmann, M.A., et al.Pharmacological properties of revefenacin (TD-4208), a novel, nebulized long-acting, and lung selective muscarinic antagonist, at human recombinant muscarinic receptors and in rat, guinea pig, and human isolated airway tissuesPharmacol. Res. Perspect.6(3),e00400(2018)
Pulido-Rios, M.T., McNamara, A., Obedencio, G.P., et al.In vivo pharmacological characterization of TD-4208, a novel lung-selective inhaled muscarinic antagonist with sustained bronchoprotective effect in experimental animal modelsJ. Pharmacol. Exp. Ther.346(2),241-250(2103)
