Clozapine N-oxide
Cat. No.：YN321123
| 产品名称: | Clozapine N-oxide |
| CAS No.: | 34233-69-7 |
| Chemical Name: | 8-chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine |
| Synonyms: | 氯氮平N-氧化 |
| 分子量: | 342.82 |
| 分子式: | C₁₈H₁₉ClN₄O |
| SMILES: | [O-][N+]1(C)CCN(C2=NC3=CC(Cl)=CC=C3NC4=CC=CC=C42)CC1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Clozapine N-oxide 是一种 Clozapine 的主要代谢产物，也是一种人毒蕈碱设计受体 (DREADDs) 激动剂。Clozapine N-oxide 可激活DREADD受体hM3Dq和hM4Di。Clozapine N-oxide 可以穿过血脑屏障。Clozapine 是一种有效的多巴胺拮抗剂，也一种是有效的选择性毒蕈碱 M4 受体 (muscarinic M4 receptor) (EC50为 11 nM) 激动剂。 |
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Eiermann, B., Engel, G., Johansson, I., et al.The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapineBr. J. Clin. Pharmacol.44(5),439-446(1997)
Armbruster, B.N., Li, X., Pausch, M.H., et al.Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligandPNAS104(12),5163-5168(2007)
Scofield, M.D., Boger, H.A., Smith, R.J., et al.Gq-DREADD selectively initiates glial glutamate release and inhibits cue-induced cocaine seekingBiol. Psychiatry78(7),441-451(2015)
