VU0357017 hydrochloride
Cat. No.：YN321244
CAS No. ：1135242-13-5
| 产品名称: | VU0357017 hydrochloride |
| CAS No.: | 1135242-13-5 |
| Chemical Name: | 4-[[2-[(2-methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid, ethyl ester, monohydrochloride |
| Synonyms: | CID-25010775 |
| 分子量: | 369.89 |
| 分子式: | C₁₈H₂₈ClN₃O₃ |
| SMILES: | O=C(N1CCC(NCCNC(C2=CC=CC=C2C)=O)CC1)OCC.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | VU0357017 hydrochloride (CID-25010775) 是一种有效、选择性和可透过血脑屏障的M1毒蕈碱乙酰胆碱受体变构激动剂，EC50值为 477 nM。VU0357017 hydrochloride 对 M1具有高度选择性，在测试的最高浓度 (30μM) 下，在M2-M5处没有活性。VU0357017 hydrochloride 可用于阿尔茨海默症和精神分裂症的研究。 |
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Digby, G.J., Utley, T.J., Lamsal, A., et al.Chemical modification of the M1 agonist VU0364572 reveals molecular switches in pharmacology and a bitopic binding modeACS Chem. Neurosci.3(12),1025-1036(2012)
Digby, G.J., Noetzel, M.J., Bubser, M., et al.Novel allosteric agonists of M1 muscarinic acetylcholine receptors induce brain region-specific responses that correspond with behavioral effects in animal modelsJ. Neurosci.32(25),8532-8544(2012)
Lebois, E.P., Bridges, T.M., Lewis, L.M., et al.Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M1 receptor function in the central nervous systemACS Chem Neurosci.1(2),104-121(2010)
